The Allegro STR 200 single-use bioreactor has been developed and tested for mammalian cell culture for the production of biopharmaceuticals and vaccines. Typical applications include:
With all product contact surfaces being single-use components, the demands on maintenance, such as cleaning and cleaning validation, are minimal. This makes single-use bioreactors the first choice for flexible manufacturing sites, as found in process development, vaccine production or CMO plants.
| Bioreactor hardware | 316 Stainless steel |
| Heating mat | Silicone |
| Biocontainer contact layer | Low density polyethylene |
| Biocontainer impeller | Polysulfone |
| Ring sparger | High density polyethylene |
| Seal housing seals | Ultra high molecular weight polyethylene |
| Biocontainer ports | Low density polyethylene |
| Standard tubing material | C-flex |
| Seal housing (external parts) | Polysulfone |
| Impeller speed | 25 to 150 rpm |
| Impeller direction | Upflow or downflow |
| Temperature range | 30 to 40 °C |
| Temperature regulation | ± 0,1 °C |
| Ring sparger aeration | Max 40 standard liters per minute |
| Overlay aeration | Max 20 standard liters per minute |
| Open pipe sparger/CO2stripping | Max 20 standard liters per minute |
| pH control | 2-12 pH, increment 0,01 |
| DO control | 0 – 200% air saturation, increment 0,1% |
| Height, width, depth | 2130 mm, 1620 mm, 1176 mm |
| Weight | Approximately 420 kg |
| Working volume | 60 – 200 liters |
| Conventional probes | 12 mm diameter and 220 to 225 mm length |
