Cphem | Модель

Bioreactor iCELLis

The iCELLis bioreactor is the world’s first fully integrated high-cell density bioreactor designed to simplify your process, by combining the advantages of single-use technologies with the benefits of a fixed-bed system. Thanks to its compact design - for a quick implementation and more ease of use –the iCELLis system represents the new generation single-use bioreactors.

Central to the iCELLis bioreactor technology is the use of a compact fixed-bed, filled with custom macrocarriers. This matrix is made of medical grade polyester microfibers and provides in only 25L volume, up to 500m² growth area available to the cells. This surface is equivalent to the surface of 3000 Roller Bottles (1700cm² each). iCELLis bioreactors are supplied pre-packed with macrocarriers. Compared to standard stirred tank bioreactor using microcarriers, the iCELLis technology leads to a dramatic simplification of cell culture process. It enables to avoid delicate and time consuming manual operations: reducing the overall process time and making the cell culture process more robust.

Model Features

  • Process simplification, from pre-culture to final product
  • The first fully-integrated, single-use bioreactor (integrated perfusion with disposable, pre-installed calibrated probes and no additional oxygen device needed)
  • Straightforward implementation for faster process development
  • Linear scalability from R&D to manufacturing
  • Compact high-cell-density, fixed-bed bioreactor providing a significant increase in volumetric productivity vs. traditional stirred tanks
  • Dramatic decrease in operational costs and capital investments