The Palltronic Flowstar LGR test instrument enables point-of-use leak testing of single-use systems up to 200 L nominal volume and provides the ability to test the integrity of the filters within the single-use systems. This technology has an extremely small footprint, is easy to use, and is compliant with current regulatory standards. The instrument allows end users to test endless configurations of single-use systems and filters, with one device, without compromising the sterility of the system.